Children born prematurely are significantly more likely to suffer brain developmental problems in their teenage years, according to new research conducted by the University of Adelaide.

 

The research, led by Dr Julia Pitcher and Dr Michael Ridding from the University of Adelaide’s Robinson Institute, found reduced plasticity, or the ability to form new neural pathways, in the brains of teenagers who were born preterm, at or before 37 weeks.

 

"Plasticity in the brain is vital for learning and memory throughout life," Dr Pitcher says. "It enables the brain to reorganise itself, responding to changes in environment, behaviour and stimuli by modifying the number and strength of connections between neurons and different brain areas. Plasticity is also important for recovery from brain damage.

 

"We know from past research that preterm-born children often experience motor, cognitive and learning difficulties. The growth of the brain is rapid between 20 and 37 weeks gestation, and being born even mildly preterm appears to subtly but significantly alter brain microstructure, neural connectivity and neurochemistry.

  

The researchers used a non-invasive magnetic brain stimulation technique to compare the brains of preterm adolescents with those born at term.

 

Levels of cortisol, normally produced in response to stress, were also measured to better understand the chemical and hormonal differences between the groups.

 

"Teenagers born preterm clearly showed reduced neuroplasticity in response to brain stimulation," Dr Pitcher says. "Surprisingly, even very modest preterm birth was associated with a reduced brain response. On the other hand, term-born teenagers were highly 'plastic' compared with adults and the preterm teens.

 

"Preterm teens also had low levels of cortisol in their saliva, which was highly predictive of this reduced brain responsiveness. People often associate increased cortisol with stress, but cortisol fluctuates up and down normally over each 24-hour period and this plays a critical role in learning, the consolidation of new knowledge into memory and the later retrieval of those memories. This might be important for the development of a possible therapy to overcome the neuroplasticity problem," she says.